Meg Griffin – Family Guy

This one is a bit unique, since Family Guy is an animated show, so it would be a little easier to notice a rescasting since one actress sounds very different from another. The Griffin’s daughter Meg was originally voiced by Lacey Chabert, who supposedly was too busy with school and Party of Five to continue.

She was replaced by now huge star Mila Kunis after the first season, which was way back in 1999. Amazingly, Family Guy is still churning out new episodes and Kunis is still the voice behind the scapegoat of the Griffin family.