Greg Serrano – Crazy Ex-Girlfriend

The comedy-drama Crazy Ex-Girlfriend actually had its recasting situation work a bit better than others on the list. The first Greg Serrano, played by Santino Fontana, left when his relationship with Rebecca ended, which coincided with Fontana going back to theater work.

The show then brought Greg back for ten episodes in the fourth and final season. However, he was played by Skylar Astin, and the show explained how perceptions change over time, so perhaps looks do too.